Free Access
Genet. Sel. Evol.
Volume 39, Number 4, July-August 2007
Page(s) 421 - 430
Published online 06 July 2007
Genet. Sel. Evol. 39 (2007) 421-430
DOI: 10.1051/gse:2007012

Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep

Zulma G. Vitezicaa, b, Carole R. Morenob, Frederic Lantierc, Isabelle Lantierc, Laurent Schiblerd, Anne Roigd, Dominique Françoisb, Jacques Bouixb, Daniel Allainb, Jean-Claude Brunele, Francis Barilletb and Jean-Michel Elsenb

a  INSERM, U.563 CHU Purpan, BP 3028, 31024 Toulouse Cedex, France
b  INRA, UR631 Station d'amélioration génétique des animaux, 31326 Castanet-Tolosan, France
c  INRA, UR1282 Unité d'infectiologie animale et santé publique, 37380 Nouzilly, France
d  INRA, UR339 Unité de génétique biochimique et cytogénétique, 78350 Jouy-en-Josas, France
e  INRA, UE332 Domaine de Bourges-La Sapinière, 18390 Osmoy, France

(Received 7 September 2006; accepted 20 February 2007; published online 6 July 2007)

Abstract - In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes.

Key words: association analysis / production trait / health trait / gene PRNP / sheep

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© INRA, EDP Sciences 2007