Free Access
Genet. Sel. Evol.
Volume 33, Number 2, March-April 2001
Page(s) 105 - 132
DOI: 10.1051/gse:2001112

OLD LINK --> Genet. Sel. Evol. 33 (2001) 105-132

Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review

Pablo M. Corva and Juan F. Medrano

Department of Animal Science, University of California, One Shields Ave., Davis, CA 956168521, USA

(Received 4 July 2000; accepted 28 November 2000)

The attainment of a specific mature body size is one of the most fundamental differences among species of mammals. Moreover, body size seems to be the central factor underlying differences in traits such as growth rate, energy metabolism and body composition. An important proportion of this variability is of genetic origin. The goal of the genetic analysis of animal growth is to understand its "genetic architecture", that is the number and position of loci affecting the trait, the magnitude of their effects, allele frequencies and types of gene action. In this review, the different strategies developed to identify and characterize genes involved in the regulation of growth in the mouse are described, with emphasis on the methods developed to map loci contributing to the regulation of quantitative traits (QTLs).

Key words: genetics / growth / mouse / mapping / QTLs

Correspondence and reprints: Juan F. Medrano OLD LINK -->

© INRA, EDP Sciences 2001