Genet. Sel. Evol.
Volume 33, Number 2, March-April 2001
|Page(s)||153 - 173|
Genet. Sel. Evol. 33 (2001) 153-173
A rapid method for computing the inverse of the gametic covariance matrix between relatives for a marked Quantitative Trait LocusGamal Abdel-Azim and Albert E. Freeman
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
(Received 23 December 1999; accepted 15 November 2000)
The inverse of the gametic covariance matrix between relatives, , for a marked quantitative trait locus (QTL) is required in best linear unbiased prediction (BLUP) of breeding values if marker data are available on a QTL. A rapid method for computing the inverse of a gametic relationship matrix for a marked QTL without building itself is presented. The algorithm is particularly useful due to the approach taken in computing inbreeding coefficients by having to compute only few elements of . Numerical techniques for determining, storing, and computing the required elements of and the nonzero elements of the inverse are discussed. We show that the subset of required for computing the inbreeding coefficients and hence the inverse is a tiny proportion of the whole matrix and can be easily stored in computer memory using sparse matrix storage techniques. We also introduce an algorithm to determine the maximum set of nonzero elements that can be found in and a strategy to efficiently store and access them. Finally, we demonstrate that the inverse can be efficiently built using the present techniques for very large and inbred populations.
Key words: gametic relationship / marker-assisted selection / best linear unbiased / prediction
Correspondence and reprints: Gamal Abdel-Azim firstname.lastname@example.org
© INRA, EDP Sciences 2001