Free Access
Genet. Sel. Evol.
Volume 36, Number 1, January-February 2004
Page(s) 65 - 81
Genet. Sel. Evol. 36 (2004) 65-81
DOI: 10.1051/gse:2003051

Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens

Marie-Hélène Pinard-van der Laana, Denis Soubieuxb, Laurence  Mératc, Danièle Bouretd, Gillette Luneaud, Ginette  Dambrineb and Pierrick Thoravalb

a  UMR Génétique et diversité animales, Institut national de la recherche agronomique, 78352 Jouy-en-Josas Cedex, France
b  Unité BioAgresseurs, Santé Environnement, Institut national de la recherche agronomique, 37380 Nouzilly, France
c  Station de pathologie aviaire et parasitologie, Institut national de la recherche agronomique, 37380 Nouzilly, France
d  Domaine du Magneraud, St-Pierre-d'Amilly, Institut national de la recherche agronomique, BP 52 17700 Surgères, France

(Received 9 December 2002; accepted 27 August 2003)

Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the B19 major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at 4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 $\pm $ 0.05 and 0.53 $\pm $ 0.06 within the progressor and regressor lines respectively, and 0.46 $\pm $ 0.03 when estimated over lines. Preliminary results showed within the progressor line a possible association between one Rfp-Y type and the growth of tumors.

Key words: chicken / selection / resistance / Rous sarcoma / Rfp-Y

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© INRA, EDP Sciences 2004