Free Access
Genet. Sel. Evol.
Volume 38, Number 2, March-April 2006
Page(s) 221 - 229
Published online 24 February 2006
Genet. Sel. Evol. 38 (2006) 221-229
DOI: 10.1051/gse:2005037

A note on QTL detecting for censored traits

Yixin Fang

Department of Statistics, Columbia University, New York, NY 10027, USA

(Received 9 August 2005; accepted 6 October 2005 ; published online 24 February 2006)

Abstract - Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".

Key words: QTL detecting / censored trait / interval mapping

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© INRA, EDP Sciences 2006