Open Access

This article has an erratum: []

Genet. Sel. Evol.
Volume 40, Number 1, January-February 2008
Page(s) 129 - 143
Published online 21 December 2007
References of  Genet. Sel. Evol. 40 (2008) 129-143
  1. Babol J., Squires E.J., Lundstrom K., Hepatic metabolism of skatole in pigs by cytochrome P4502E1, J. Anim. Sci. 76 (1998) 822-828 [PubMed].
  2. Babol J., Squires E.J., Lundstrom K., Relationship between oxidation and conjugation metabolism of skatole in pig liver and concentrations of skatole in fat, J. Anim. Sci. 76 (1998) 829-838 [PubMed].
  3. Babol J., Squires E.J., Lundstrom K., Relationship between metabolism of androstenone and skatole in intact male pigs, J. Anim. Sci. 77 (1999) 84-92.
  4. Bidanel J.P., Riquet J., Gruand J., Squires E.J., Bonneau M., Milan D., Detection of quantitative trait loci for skatole and indole levels in Meishan $\times$ Large White F2 Pigs, 8th WCGALP, August 13-18 2006, Belo Horizonte, Brazil.
  5. Bonneau M., Boar taint in entire male pigs-a review, Pig News Inf. 18 (1997) 15-18.
  6. Brooks R.I., Pearson A.M., Steroid hormone pathways in the pig, with special emphasis on boar odor: a review, J. Anim. Sci. 62 (1986) 632-645 [PubMed].
  7. Cheung C., Akiyama T.E., Kudo G., Gonzalez F.J., Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice, Biochem. Pharmacol. 66 (2003) 2011-2020 [CrossRef] [PubMed].
  8. Claus R., [Mammalian pheromones with special reference to the boar taint steroid and its relationship to other testicular steroids (author's transl.)], Fortschr. Tierphysiol. Tierernahr. 10 (1979) 1-136 [PubMed].
  9. Claus R., Weiler U., Herzog A., Physiological aspects of androstenone and skatole formation in the boar - a review with experimental data, Meat Sci. 38 (1994) 289-305 [CrossRef].
  10. Cue R.A., Nicolau-Solano S.I., McGivan J.D., Wood J.D., Doran O., Breed-associated variations in the sequence of the pig 3$\beta$-hydroxysteroid dehydrogenase gene, J. Anim. Sci. 85 (2007) 571-576 [CrossRef] [PubMed].
  11. Davis S.M., Squires E.J., Association of cytochrome b5 with 16-androstene steroid synthesis in the testis and accumulation in the fat of male pigs, J. Anim. Sci. 77 (1999) 1230-1235 [PubMed].
  12. Diaz G.J., Squires E.J., Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes, Toxicol. Sci. 55 (2000) 284-292 [CrossRef] [PubMed].
  13. Doran E., Whittington F.W., Wood J.D., McGivan J.D., Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes, Chem. Biol. Interact. 140 (2002) 81-92 [CrossRef] [PubMed].
  14. Doran E., Whittington F.M., Wood J.D., McGivan J.D., Characterisation of androstenone metabolism in pig liver microsomes, Chem. Biol. Interact. 147 (2004) 141-149 [CrossRef] [PubMed].
  15. Fouilloux M.N., Le Roy P., Gruand J., Renard C., Sellier P., Bonneau M., Support for single major genes influencing fat androstenone level and development of bulbo-urethral glands in young boars, Genet. Sel. Evol. 29 (1997) 357-366 [CrossRef] [EDP Sciences].
  16. Gower D.B., 16-Unsaturated C 19 steroids. A review of their chemistry, biochemistry and possible physiological role, J. Steroid Biochem. 3 (1972) 45-103 [CrossRef] [PubMed].
  17. Greger D., Genetic marker for meat quality, growth, carcass and reproductive traits in livestock, patent WO 0/69882, Washington, DC (2000).
  18. Jensen M.T., Cox R.P., Jensen B.B., 3-Methylindole (skatole) and indole production by mixed populations of pig fecal bacteria, Appl. Environ. Microbiol. 61 (1995) 3180-3184 [PubMed].
  19. Katkov T., Gower D.B., The biosynthesis of androst-16-enes in boar testis tissue, Biochem. J. 117 (1970) 533-538 [PubMed].
  20. Kwan T.T., Orengo C., Gower D.B., Biosynthesis of androgens and pheromonal steroids in neonatal porcine testicular preparations, FEBS letters 183 (1985) 359-364 [CrossRef] [PubMed].
  21. Lee G.J., Archibald A.L., Law A.S., Lloyd S., Wood J., Haley C.S., Detection of quantitative trait loci for androstenone, skatole and boar taint in a cross between Large White and Meishan pigs, Anim. Genet. 36 (2005) 14-22 [CrossRef] [PubMed].
  22. Lin Z., Lou Y., Squires E.J., Molecular cloning, expression and functional characterization of the cytochrome P450 2A6 gene in pig liver, Anim. Genet. 35 (2004) 314-316 [CrossRef] [PubMed].
  23. Lin Z., Lou Y., Squires E.J., Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: a single mutation SULT1A1 causes a significant decrease in sulfation activity, Mamm. Genome 15 (2004) 218-226 [CrossRef] [PubMed].
  24. Lin Z., Lou Y., Peacock J., Squires J.E., A novel polymorphism in the 5' untranslated region of the porcine cytochrome b5 (CYB5) gene is associated with decreased fat androstenone level, Mamm. Genome 16 (2005) 367-373 [CrossRef] [PubMed].
  25. Lin Z., Lou Y., Squires E.J., Identification of a single nucleotide polymorphism in porcine testis cytochrome P450-c17 (CYP17) and its effect on steroidogenesis, Biochem. Genet. 43 (2005) 531-542 [CrossRef] [PubMed].
  26. Lin Z., Lou Y., Squires E.J., Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels, J. Steroid Biochem. Mol. Biol. 99 (2006) 231-237 [CrossRef] [PubMed].
  27. Lundström K., Malmfors B., Stern S., Rydhmer L., Eliasson-Selling L., Mortensen A.B., Mortensen H.P., Skatole levels in pigs selected for high lean tissue growth rate on different dietary protein levels, Livest. Prod. Sci. 38 (1994) 135-132.
  28. Maher J.M., Slitt A.L., Callaghan T.N., Cheng X., Cheung C., Gonzalez F.J., Klaassen C.D., Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1$\alpha$, Biochem. Pharmacol. 72 (2006) 512-522 [CrossRef] [PubMed].
  29. Nicolau-Solano S.I., McGivan J.D., Whittington F.M., Nieuwhof G.J., Wood J.D., Doran O., Relationship between the expression of hepatic but not testicular 3$\beta$-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue, J. Anim. Sci. 84 (2006) 2809-2817 [CrossRef] [PubMed].
  30. Patterson R.L.S., 5a-androst-16-ene-3-one, compound responsible for taint in boar fat, J. Sci. Food Agric. 19 (1968) 31-38 [CrossRef].
  31. Pedersen B., Heritability of skatole in back fat, in: Jensen W.K. (Ed.), Skatole and boar taint, Roskilde, Denmark, Danish Meat Research Institute (1998) 129-136.
  32. Quintanilla R., Milan D., Bidanel J.P., A further look at quantitative trait loci affecting growth and fatness in a cross between Meishan and Large White pig populations, Genet. Sel. Evol. 34 (2002) 193-210 [CrossRef] [PubMed] [EDP Sciences].
  33. Quintanilla R., Demeure O., Bidanel J.P., Milan D., Iannuccelli N., Amigues Y., Gruand J., Renard C., Chevalet C., Bonneau M., Detection of quantitative trait loci for fat androstenone levels in pigs, J. Anim. Sci. 81 (2003) 385-394 [PubMed].
  34. Robic A., Faraut T., Iannuccelli N., Lahbib-Mansais Y., Cantegrel V., Alexander L., Milan D., A new contribution to the integration of human and porcine genome maps: 623 new points of homology, Cytogenet. Genome Res. 102 (2003) 100-108 [CrossRef] [PubMed].
  35. Sellier P., Genetics of meat and carcass traits, in: Rothschild M.F., Ruvinsky A. (Eds.), The Genetics of the Pig, CAB International, Wallingford, Oxon, UK, 1998, pp. 463-510.
  36. Sellier P., Le Roy P., Fouilloux M.N., Gruand J., Bonneau M., Responses to restricted index selection and genetic parameters for fat androstenone level and sexual maturity status of young boars, Livest. Prod. Sci. 63 (2000) 265-274 [CrossRef].
  37. Sinclair P.A., Hancock S., Gilmore W.J., Squires E.J., Metabolism of the 16-androstene steroids in primary cultured porcine hepatocytes, J. Steroid Biochem. Mol. Biol. 96 (2005) 79-87 [CrossRef] [PubMed].
  38. Sinclair P.A., Squires E.J., Testicular sulfoconjugation of the 16-androstene steroids by hydroxysteroid sulfotransferase: its effect on the concentrations of 5$\alpha$-androstenone in plasma and fat of the mature domestic boar, J. Anim. Sci. 83 (2005) 358-365 [PubMed].
  39. Sinclair P.A., Squires E.J., Raeside J.I., Renaud R., Synthesis of free and sulphoconjugated 16-androstene steroids by the Leydig cells of the mature domestic boar, J. Steroid Biochem. Mol. Biol. 96 (2005) 217-228 [CrossRef] [PubMed].
  40. Sinclair P.A., Gilmore W.J., Lin Z., Lou Y., Squires E.J., Molecular cloning and regulation of porcine SULT2A1: relationship between SULT2A1 expression and sulfoconjugation of androstenone, J. Mol. Endocrinol. 36 (2006) 301-311 [CrossRef] [PubMed].
  41. Skinner T.M., Doran E., McGivan J.D., Haley C.S., Archibald A.L., Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig, Anim. Genet. 36 (2005) 417-422 [CrossRef] [PubMed].
  42. Skinner T.M., Anderson J.A., Haley C.S., Archibald A.L., Assessment of SULT1A1, CYP2A6 and CYP2C18 as candidate genes for elevated backfat skatole levels in commercial and experimental pig populations, Anim. Genet. 37 (2006) 521-522 [CrossRef] [PubMed].
  43. Squires E.J., Lundstrom K., Relationship between cytochrome P450IIE1 in liver and levels of skatole and its metabolites in intact male pigs, J. Anim. Sci. 75 (1997) 2506-2511 [PubMed].
  44. Stewart J.D., Lou Y., Squires E.J., Coussens P.M., Using human microarrays to identify differentially expressed genes associated with increased steroidogenesis in boars, Anim. Biotechnol. 16 (2005) 139-151 [CrossRef] [PubMed].
  45. Tajet H., Andresen O., Meuwissen T.E., Estimation of genetic parameters for boar taint: skatole and androstenone and their correlations with sexual maturation., Acta Vet. Scand. 48 (Suppl. 1) S9 (2006) 22-23.
  46. Tambyrajah W.S., Doran E., Wood J.D., McGivan J.D., The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone, Arch. Biochem. Biophys. 431 (2004) 252-260 [CrossRef] [PubMed].
  47. Terner M.A., Gilmore W.J., Lou Y., Squires E.J., The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes, Drug Metab. Dispos. 34 (2006) 848-854 [CrossRef] [PubMed].
  48. Varona L., Vidal O., Quintanilla R., Gil M., Sanchez A., Folch J.M., Hortos M., Rius M.A., Amills M., Noguera J.L., Bayesian analysis of quantitative trait loci for boar taint in a Landrace outbred population, J. Anim. Sci. 83 (2005) 301-307 [PubMed].
  49. Vold E., Fleishprouktionseigenschaften bei Ebern und Kastraten: IV. Organoleptische und gaschromatografische untersuchungen wasserdampffluchtiger stoffe des ruckenpeckes von ebern, Meldinger fra Norges Landbrukshogskole 49 (1970) 1-25.
  50. Weiler U., Font Furnols M., Fischer K., Kemmer H., Oliver M.A., Gispert M., Dobrowolski A., Claus R., Influence of differences in sensitivity of Spanish and German consumers to perceive androstenone on the acceptance of boar meat differing in skatole and androstenone concentrations, Meat Sci. 54 (2000) 297-304 [CrossRef].
  51. Wysocki C.J., Beauchamp G.K., Ability to smell androstenone is genetically determined, Proc. Natl. Acad. Sci. USA 81 (1984) 4899-4902 [CrossRef] [PubMed].
  52. Yost G.S., Mechanisms of 3-methylindole pneumotoxicity, Chem. Res. Toxicol. 2 (1989) 273-279 [CrossRef] [PubMed].
  53. Zamaratskaia G., Gilmore W.J., Lundstrom K., Squires E.J., Effect of testicular steroids on catalytic activities of cytochrome P450 enzymes in porcine liver microsomes, Food Chem. Toxicol. 45 (2007) 676-681 [CrossRef] [PubMed].