Free Access
Genet. Sel. Evol.
Volume 35, Number Suppl. 1, 2003
Second International Symposium on Candidate Genes for Animal Health
Page(s) S83 - S96


  1. Ameratunga R., Winkelstein J.A., Brody L., Binns M., Cork L.C., Colombani P., Valle D., Molecular analysis of the third component of canine complement (C3) and identification of the mutation responsible for hereditary canine C3 deficiency, J. Immunol. 160 (1998) 2824-2830.
  2. Antonarakis S.E., Nomenclature Working Group, Recommendations for a nomenclature system for human gene mutations, Hum. Mutat. 11 (1998) 1-3.
  3. Botto M., Fong K.Y., So A.K., Rudge A., Walport M.J., Molecular basis of hereditary C3 deficiency, J. Clin. Invest. 86 (1990) 1158-1163.
  4. Botto M., Fong K.Y., So A.K., Barlow R., Routier R., Morley B.J., Walport M.J., Homozygous hereditary C3 deficiency due to a partial gene deletion, Proc. Natl. Acad. Sci. USA 89 (1992) 4957-4961.
  5. Circolo A., Garnier G., Fukuda W., Wang X., Hidvegi T., Szalai A.J., Briles D.E., Volanakis J.E., Wetsel R.A., Colten H.R., Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA, Immunopharmacology 42 (1999) 135-149.
  6. de Bruijn M.H., Fey G.H., Human complement component C3: cDNA coding sequence and derived primary structure, Proc. Natl. Acad. Sci. USA 82 (1985) 708-712.
  7. Fey G.H, Lundwall A., Wetsel R.A., Tack B.F., de Bruijn M.H., Domdey H., Nucleotide sequence of complementary DNA and derived amino acid sequence of murine complement protein C3, Philos. Trans R. Soc. Lond. B. Biol. Sci. 306 (1984) 333-344.
  8. Fong K.Y., Botto M., Walport M.J., So A.K., Genomic organization of human complement component C3, Genomics 7 (1990) 579-586.
  9. Hardge T., Köpke K., Reißmann M., Wimmers K., Maternal influences on litter size and growth in reciprocal crossed miniature pigs and Durocs, Arch. Tierz. Dummerstorf 42 (1999) 83-92.
  10. Kawamura N., Singer L., Wetsel R.A., Colten H.R., Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene, Biochem. J. 283 (1992) 705-712.
  11. Komatsu M., Yamamoto K., Nakano Y., Nakazawa M., Ozawa A., Mikami H., Tomita M., Migita S., Hereditary C3 hypocomplementemia in the rabbit, Immunology 64 (1988) 363-368.
  12. Komatsu M., Yoshiwara S., Akita T., Immunological characteristics of the meishan pig: serum complement activity, serum C3 level, immune response and skin structure, in: Proceedings of the 6th World Congress on Genetics Applied to Livestock Production, 11-16 January 1998, Vol. 26, University of New England, Armidale, pp. 323-326.
  13. Kopf M., Abel B., Gallimore A., Carroll M., Bachmann M.F., Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection, Nat. Med. 8 (2002) 373-378.
  14. Littell R.C., Henry P.R., Ammerman C.B., Statistical analysis of repeated measures data using SAS® procedures, J. Anim. Sci. 76 (1998) 1216-1231.
  15. Liu C.C., Young J.D., A semiautomated microassay for complement activity, J. Immunol. Methods 114 (1988) 33-39.
  16. Mallard B.A., Wilkie B.N., Kennedy B.W., Influence of major histocompatibility genes on serum hemolytic complement activity in miniature swine, Am. J. Vet. Res. 50 (1989) 359-363.
  17. Misumi Y., Sohda M., Ikehara Y., Nucleotide and deduced amino acid sequence of rat complement C3, Nucleic Acids Res. 25 (1990) 2178.
  18. Ren Y., Liao W.S., Transcription factor AP-2 functions as a repressor that contributes to the liver-specific expression of serum amyloid A1 gene, J. Biol. Chem. 276 (2001) 17770-17778.
  19. Sahu A., Lambris J.D., Structure and biology of complement protein C3, a connecting link between innate and acquired immunity, Immunol. Rev. 180 (2001) 35-48.
  20. Vaiman M., Hauptmann G., Mayer S., Influence of the major histocompatibility complex in the pig (SLA) on serum haemolytic complement levels, J. Immunogenet. 5 (1978) 59-65.
  21. Vik D.P., Amiguet P., Moffat G.J., Fey M., Amiguet-Barras F., Wetsel R.A., Tack B.F., Structural features of the human C3 gene: intron/exon organization, transcriptional start site, and promoter region sequence, Biochemistry 30 (1991) 1080-1085.
  22. Wessels M.R., Butko P., Ma M., Warren H.B., Lage A.L., Carroll M.C., Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity, Proc. Natl. Acad. Sci. USA 92 (1995) 11490-11494.
  23. Wilson D.R., Juan T.S., Wilde M.D., Fey G.H., Darlington G.J., A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6, Mol. Cell Biol. 10 (1990) 6181-6191.
  24. Wimmers K., Lipperheide C., Ponsuksili S., Schmoll F., Hardge T., Petersen B., Schellander K., Haemolytic complement activity and C3c serum concentration in pigs, Arch. Tierz. Dummerstorf 42 (1999) 93-102.
  25. Wimmers K., Mekchay S., Ponsuksili S., Hardge T., Schellander K., Polymorphic sites in exon 15 and 30 of the porcine C3 gene, Anim. Genet. 32 (2001) 46-47.


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